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(2019) investigated the influence of RBC unit exposure to pyruvate, inosine, phosphate, and adenine (PIPA) solution on metabolite profiles in the blood of sickle cell disease patients (a RBC transfusate treatment schematized in Figure 2)

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Some researchers believe the autonomic nervous system effects of GLP-1 receptor activation also play a role, altering the parasympathetic signaling that controls salivary gland function

Data indicate that GLP-1s may reduce inflammation and tau phosphorylation and improve synaptic function

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